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Asenapine co-administration lowered the DX/DM ratio to 0.43, While paroxetine co-administration reduced this ratio to 0.032, consistent with the identified considerable in vivo CYP2D6 inhibition produced by paroxetine (Desk 1). Based upon these studies, asenapine and/or maybe a metabolite of asenapine may improve the recognised inhibitory consequen… Read More